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Title   중등도 이상의 후흉선 T세포 림프종과 미만성 B세포 림프종의 임상상의 비교 ( Clinicopathologic Comparison of Intermediate or High Grede Peripheral T-Cell Lymphoma with Diffuse B-Cell Lymphoma )
Publicationinfo   1997 Jan; 029(01): 136-146.
Key_word   Peripheral T-cell lymphoma, Diffuse B-cell lymphoma, Intermediate or high grade, Survival
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Abstract   Purpose: Peripheral T-cell lymphoma(PTCL) derived from mature T cells forms morphologically diverse group of non-Hodgkins lymphomas and the clinicopathologic features remain to be debated. In order to elucidate the specific characteristics of PTCL, comparison with a group of diffuse B-cell lymphomas(DBCL) was done. Materials and Methods: Between Dec. 1989 and Feb. 1993, clinical data of 67 cases of intermediate or high grade NHL identified as T-cell or B-cell origin by immunophenotyping was reviewed. Results: There were 30 cases of PTCL and 37 cases of DBCL. PTCL had more advanced stage and B symptoms at diagnosis. Frequent sites of extranodal involvement were bone marrow, nasal cavity/paranasal sinus, and skin in PTCL and gastrointestinal tract in DBCL. Based on NCI Working Formulation, 40% of PTCL and 14% of DBCL were high grade. Patients with DBCL had a better 3-year overall survival rate(67% vs 47%), however, there was no difference in complete remission rate and disease-free survival rate between two groups with intensive treatment. A subgroup of PTCL patients who had died earlier was found to have more advanced stage and poor performance status. Conclusion: Although patients with PTCL had worse survival in advanced stage, the outcome of patients with PTCL who received intensive treatment was comparable to that of DBCL.
저 자   정경해(Kyung Hae Jung),우인숙(In Sook Woo),장흥문(Heung Moon Chang),허대석(Dae Seog Heo),방영주(Yung Jue Bang),김철우(Chul Woo Kim),박선양(Seon Yang Park),김병국(Byoung Kook Kim),김노경(Noe Kyeong Kim)